Breaking the 20 nm Barrier: Redefining Single-Particle Analysis.

Vertex electron microscopy-level resolution enables accurate detection of viral particle aggregation, setting a new industry standard for AAV product quality control.

Particle size range: 15 - 60 nm

Ultra-wide concentration detection range: 10¹⁰ - 10¹² particles/mL

Accurate counting in just 2 - 3 minutes with 1 nm resolution.

Compatible sample types: AAV / small VLPs

Unparalleled Detection Performance

Particle size measurement precision comparable to electron microscopy

The NanoCoulter^TM measures the average particle size and size distribution of polystyrene standard microspheres and other polydisperse samples,producing results that are fully consistent with SEM data, offering exceptionally high accuracy and precision.

Measure concentration with high accuracy and repeatability

Samples were diluted in a gradient, and the concentration detection data showed a good linear relationship, consistent with the theoretical concentration（R² > 0.99）. With 10 repeated tests, the coefficient of variation (CV) was less than 5%.

Related Cases

Adeno-Associated Virus (AAV) Particle Concentration Quantification

AAV Particle Concentration Linearity R² > 0.999

AAV Aggregation Analysis & Batch-to-Batch Quality Control

The aggregation levels (>30 nm) of both samples are similar, accounting for only about 10% of the total particle count.

Latest Articles & News

Introducing the New NanoCoulter™ Vertex Series: Precision Characterization for AAV and Sub-50 nm Nanoparticles

June 13, 2025

AAVs are promising gene therapy vectors due to their small size and favorable safety profile. However, accurately characterizing these sub-50 nm particles remains a major technical challenge in the field.

NanoCoulter™ Empowers Breakthrough Exosome Research in Cutting-Edge Biomedical Studies

June 13, 2025

A recent study employed the NanoCoulter particle analyzer, based on resistive pulse sensing (RPS) technology, to comprehensively evaluate five commonly used EV isolation methods, providing valuable insights for researchers.

PDI vs. SPAN: Which Metric Best Represents Particle Size Distribution?

June 13, 2025

In the fields of nanotechnology and materials science, particle size distribution (PSD) is a critical parameter that directly influences the performance and applicability of nanomaterials. Two of the most commonly used indicators to evaluate PSD are the Polydispersity Index (PDI) and the SPAN value. While often used interchangeably, these two metrics differ significantly in how they are calculated and interpreted. Understanding the distinction between PDI and SPAN is essential for accurate particle characterization.