NanoCoulter™ Deft can simultaneously measure the size and zeta potential of individual particles, with each size corresponding to a specific zeta potential.

Wider particle size range: 50 - 2000 nm
Single-particle zeta potential measurement

Unparalleled Detection Performance

Single-Particle Zeta Potential Measurement

NanoCoulter™ measures both the particle size and size distribution of polydisperse samples, delivering EM-consistent results with exceptional accuracy and precision.

Single-Particle Zeta Potential Measurement

Zeta potential is an important indicator of the stability of dispersion systems. Under a constant electric field, the electrophoretic velocity of particles is directly proportional to the absolute value of their zeta potential. NanoCoulter™ measures the time it takes for particles to pass through a nanopore to obtain Zeta potential data, making it the only technology platform capable of simultaneously measuring single-particle size, Zeta potential, and concentration.

Related Cases

Nanodrug Surface Property Analysis

Surface coating or functional modifications of nanodrugs affect aggregation behavior, stability, biocompatibility, circulation time, and targeted delivery. NanoCoulter™ enables simultaneous single-particle zeta potential and size measurement, providing detailed population analysis for a deeper understanding of nanodrug stability and performance.

Quality Control for Lot-to-Lot Variability of Viruses.

Real-time monitoring of particle size and Zeta potential distribution for lentivirus, adenovirus, etc., enables precise assessment of batch-to-batch differences. This provides efficient support for process optimization and adjustment of production parameters, helping to improve viral production efficiency and stability.

Characterization of Microsphere Modification Process

Perform precise particle size and surface charge analysis on latex microspheres before and after antibody coating to intuitively reveal the aggregation status. This provides reliable data support for optimizing the coating process and dispersion treatment, thereby enhancing the stability of downstream experiments.

Latest Articles & News

AAVs are promising gene therapy vectors due to their small size and favorable safety profile. However, accurately characterizing these sub-50 nm particles remains a major technical challenge in the field.
Recently, NanoCoulter™ has gained growing recognition in exosome research, with multiple studies validating its analytical strengths. Below are highlights from several key publications.
In the fields of nanotechnology and materials science, particle size distribution (PSD) is a critical parameter that directly influences the performance and applicability of nanomaterials. Two of the most commonly used indicators to evaluate PSD are the Polydispersity Index (PDI) and the SPAN value. While often used interchangeably, these two metrics differ significantly in how they are calculated and interpreted. Understanding the distinction between PDI and SPAN is essential for accurate particle characterization.