Simultaneously obtain multi-dimensional data on particle size, concentration in a single measurement.
Unparalleled Detection Performance
Particle size measurement precision comparable to electron microscopy
The NanoCoulterTM measures the average particle size and size distribution of polystyrene standard microspheres and other polydisperse samples,producing results that are fully consistent with SEM data, offering exceptionally high accuracy and precision.
Measure concentration with high accuracy and repeatability
Samples were diluted in a gradient, and the concentration detection data showed a good linear relationship, consistent with the theoretical concentration（R2 > 0.99）. With 10 repeated tests, the coefficient of variation (CV) was less than 5%.
Related Cases
MISEV Recommends RPS for EV Characterization
“RPS measurements do have very high concordance with TEM data.” —MISEV 2023
RPS technology, a non-optical method, is ideal for orthogonal validating TEM and flow cytometry. NanoCoulter™ offers accurate size distribution analysis with a wide detection range (50-800 nm) and concentrations (5×10⁷-2×10¹¹ particles/mL), making it indispensable for EV research.”
Investigation of EV Isolation Methods
EVs purification often requires multiple steps. NanoCoulter™ quickly and accurately evaluates the impact of different methods on size and concentration.
Rapid Quantification of Exosome Purity
Exosome purity can be assessed by comparing particle counts before and after Triton X-100 lysis. A 87.2% purity was calculated, with a significant drop in particle number post-lysis—demonstrating effective membrane disruption and high sample quality.
Stability Study of Liposomal Drug
NanoCoulter™ precisely evaluates Liposome stability which varies and impacts the drug usage. The concentration changes of two liposome samples after vortex reveals the better stability of Sample 2.
Particle Size Composition & Zeta Potential Analysis of LNPs
Particle size and distribution are CQA for LNP drugs, varying with preparation methods and these differences are often misrepresented by DLS. NanoCoulter™ accurately analyzes size distribution, concentration, and percentage of custom-gated size fractions, while precisely correlating individual particle size with zeta potential across various LNP formulations.
Aggregation Analysis of Poxvirus
The virus’s storage conditions impact aggregation, with increased aggregates reducing infectivity. NanoCoulterTM, with its high particle size resolution, is one of the best methods, aside from TEM. for quickly and accurately assessing aggregation. As shown, under two storage conditions, virus particles in Condition 2 are more dispersed.
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