NanoCoulter™ is an expert in single particle characterization.

Wider particle size range: 50 - 2000 nm
Single-particle zeta potential measurement

Unparalleled Detection Performance

Simultaneous single-particle size and zeta potential measurement.

Zeta potential is an important indicator of the stability of dispersion systems. Under a constant electric field, the speed at which particles move is positively correlated with the absolute value of the Zeta potential. NanoCoulter measures the time it takes for particles to pass through a nanopore to obtain Zeta potential data, making it the only technology platform capable of simultaneously measuring single-particle size, Zeta potential, and concentration.

Related Cases

Nanodrug Surface Property Analysis

Surface coating or functional modifications of nanodrugs affect aggregation behavior, stability, biocompatibility, circulation time, and targeted delivery. NanoCoulter™ enables simultaneous single-particle zeta potential and size measurement, providing detailed population analysis for a deeper understanding of nanodrug stability and performance.

Real-Time Monitoring of Lentivirus & Adenovirus Size and Zeta Potential

NanoCoulter™ enables real-time measurement of particle size and zeta potential distribution for lentivirus and adenovirus, providing precise batch-to-batch variation analysis. This supports process optimization and production parameter adjustments, enhancing viral manufacturing efficiency and stability.

Microsphere Surface Modification Characterization

NanoCoulter™ provides accurate size and surface charge measurements of latex microspheres before and after antibody coating, offering direct insights into aggregation behavior. This data supports optimization of coating processes and dispersion treatments, enhancing the stability of downstream experiments.

Latest Articles & News

AAVs are promising gene therapy vectors due to their small size and favorable safety profile. However, accurately characterizing these sub-50 nm particles remains a major technical challenge in the field.
A recent study employed the NanoCoulter particle analyzer, based on resistive pulse sensing (RPS) technology, to comprehensively evaluate five commonly used EV isolation methods, providing valuable insights for researchers.
In the fields of nanotechnology and materials science, particle size distribution (PSD) is a critical parameter that directly influences the performance and applicability of nanomaterials. Two of the most commonly used indicators to evaluate PSD are the Polydispersity Index (PDI) and the SPAN value. While often used interchangeably, these two metrics differ significantly in how they are calculated and interpreted. Understanding the distinction between PDI and SPAN is essential for accurate particle characterization.