Articles & News
Introducing the New NanoCoulter™ Vertex Series: Precision Characterization for AAV and Sub-50 nm Nanoparticles
With the rapid advancement of gene therapy, adeno-associated viruses (AAVs) and other sub-50 nm nanoparticles are playing an increasingly critical role in biopharmaceutical development. As one of the smallest known single-stranded DNA viruses—measuring just 20–26 nm in diameter—AAVs offer several advantages over adenoviruses, including low immunogenicity, broad tissue tropism, long-term gene expression, and high safety profiles. These features make AAVs promising vectors for next-generation gene therapies.
However, comprehensive and precise characterization of AAVs—covering particle size, concentration, structural integrity, genome loading efficiency, and infectivity—is essential to ensure their quality, safety, and therapeutic efficacy. Yet, current nanoparticle analysis technologies face major limitations in accurately analyzing such small and polydisperse viral particles, especially below the 50 nm threshold. This has left a critical gap in the field.
Engineered for Sub-50 nm Nanoparticle Analysis
To meet this unmet need, Resuntech is proud to launch the NanoCoulter™ Vertex Series—a next-generation, ultra-sensitive particle analyzer purpose-built for characterizing nanoparticles down to 20 nm. Leveraging our proprietary solid-state nanopore technology, the Vertex Series delivers unparalleled resolution and sensitivity for particle size and concentration analysis, setting a new standard for AAV, small VLPs, and LNP characterization.
Compared to conventional methods such as DLS and NTA, the Vertex Series excels in resolving size distributions and number concentrations for small, heterogeneous particles that are otherwise difficult to quantify.
High-Resolution, Multi-Parameter Characterization
Equipped with our latest electrical sensing module, the NanoCoulter™ Vertex Series enables high-resolution, single-particle detection with exceptional sensitivity. From accurate sizing of individual AAV particles to precise quantification of vector concentration, the Vertex Series provides critical insights across both R&D and quality control pipelines.
Whether it’s particle purification, stability testing, or batch-to-batch consistency evaluation, the Vertex Series offers rich data outputs to ensure the uniformity and reliability of every product lot.
Intuitive Operation, Streamlined Workflow
Despite its advanced capabilities, the Vertex Series is remarkably easy to use. Its streamlined design and user-friendly interface ensure a smooth learning curve and faster results—empowering researchers to focus on discovery rather than instrumentation. The system is well-suited not only for academic and industrial research but also for routine quality control in production environments.
The NanoCoulter™ Vertex represents Resuntech’s continued commitment to innovation in nanoparticle analytics. Whether you’re working with AAV vectors, drug delivery nanoparticles, or next-gen gene therapy systems, the Vertex Series offers the precision and performance you need to drive breakthroughs in nanomedicine.
To support the scientific community, Resuntech is offering free sample testing services—helping accelerate your research with accurate, high-resolution nanoparticle data. Let us support your journey to nanoscale discovery.
